Insight into the structures of Interleukin-18 systems.

Insight into the structures of Interleukin-18 systems.
Comput Biol Chem. 2020 Jul 31;88:107353
Authors: Roy U
Abstract
Structure-based molecular designs play a critical role in the context of next generation drug development. Besides their fundamental scientific aspects, the findings established in this approach have significant implications in the expansions of target-based therapies and vaccines. Interleukin-18 (IL-18), also known as interferon gamma (IFN-γ) inducing factor, is a pro-inflammatory cytokine. The IL-18 binds first to the IL-18α receptor and forms a lower affinity complex. Upon binding with IL-18β a hetero-trimeric complex with higher affinity is formed that initiates the signal transduction process. The present study, including structural and molecular dynamics simulations, takes a close look at the structural stabilities of IL-18 and IL-18 receptor-bound ligand structures as functions of time. The results help to identify the conformational changes of the ligand due to receptor binding, as well as the structural orders of the apo and holo IL-18 protein complexes.
PMID: 32769049 [PubMed - as supplied by publisher]

Source: Computational Biology and Chemistry - July 30, 2020 Category: Bioinformatics Authors: Roy U Tags: Comput Biol Chem Source Type: research