Population Pharmacokinetics of IV Phenobarbital in Neonates After Congenital Heart Surgery

Conclusions: In neonates following cardiac surgery, phenobarbital clearance increased with postnatal age. Volume of distribution increased with extracorporeal membrane oxygenation and lower albumin values. Loading doses of 30 mg/kg on extracorporeal membrane oxygenation and 20–30 mg/kg without extracorporeal membrane oxygenation were needed to reach goal concentration based on simulations.
Source: Pediatric Critical Care Medicine - Category: Pediatrics Tags: Online Cardiac Intensive Care Source Type: research