Airway guidance for the endemic phase of COVID-19, FICM (published 11th August 2020)

Consensus airway guidelines from the Difficult Airway Society (DAS), Association of Anaesthetists, Intensive Care Society, Faculty of Intensive Care Medicine and Royal College of Anaesthetists (RCoA) were published on the 2 External 0 0 0 Anaesthesia-Intensive Care Medicine hub false https://icmanaesthesiacovid-19.org/covid-19-airway-management-principles true false%> website in April 2020 and subsequently 2 External 0 0 0 in the journal Anaesthesia false https://onlinelibrary.wiley.com/doi/full/10.1111/anae.15054 true false%>. These focus mainly on management of critically ill patients with confirmed or suspected COVID-19. It is now apparent that SARS-CoV-2 and COVID-19 will remain endemic for some time. Improved therapeutics and a vaccine may shorten this period, but both are far from certain. Plans must be put in place on the assumption that for the next few years the virus and its disease will impact us and our patients. Guidance Review Date: 11 November 2020.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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In conclusion, our study suggests that SARS-CoV-2 antibodies need to be searched in the serum and CSF in patients with GBS living in endemic areas, even in the absence of a clinically severe COVID- 19 infection, and that IL-8 pathway can be relevant in Si-GBS pathogenesis. Further studies are needed to conclude on the relevance of the genetic findings, but it is likely that HLA plays a role in this setting as in other autoimmune neurological syndromes, including those triggered by infections.
Source: Neurological Sciences - Category: Neurology Source Type: research
CONCLUSIONS: The endemic common respiratory pathogens are more prevalent than SARS-CoV-2 in the SARS-CoV-2 non-epidemic areas of this research. Detection of the pathogen is the unique means for definite COVID-19 diagnosis. PMID: 32965014 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Authors: Naeem U, Naeem A, Naeem MA, Naeem K, Mujtaba B, Mujtaba A, Khurshid A Abstract OBJECTIVE: Our objective was to find an association between exposure of a population to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and mortality rate due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) across different countries worldwide. MATERIALS AND METHODS: To find the relationship between exposure to MERS-CoV and mortality rate due to SARS-CoV-2, we collected and analyzed data of three possible factors that may have resulted in an exposure of a population to MERS-CoV: (1) the number of Midd...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Basel, 18 September 2020 - Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced the launch of its Elecsys ® Anti-SARS-CoV-2 S antibody test for markets accepting the CE Mark. Roche has filed for Emergency Use Authorisation (EUA) from the U.S. Food and Drug Administration (FDA). The Elecsys Anti-SARS-CoV-2 serology test can be used to quantitatively measure antibodies in people who have been exposed to the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and can play an important part in characterising a vaccine-induced immune response.1 Specifically, the test targets antibodies which are directed against the ...
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
Authors: Reta DH, Tessema TS, Ashenef AS, Desta AF, Labisso WL, Gizaw ST, Abay SM, Melka DS, Reta FA Abstract Viral infections are causing serious problems in human population worldwide. The recent outbreak of coronavirus disease 2019 caused by SARS-CoV-2 is a perfect example how viral infection could pose a great threat to global public health and economic sectors. Therefore, the first step in combating viral pathogens is to get a timely and accurate diagnosis. Early and accurate detection of the viral presence in patient sample is crucial for appropriate treatment, control, and prevention of epidemics. Here, we s...
Source: International Journal of Microbiology - Category: Microbiology Tags: Int J Microbiol Source Type: research
Frailty is a geriatric state of reduced functional reserve and vulnerability that represent a major public health problem because of its relationship with systemic diseases, increased risk for hospitalization, institutionalization, and all-cause mortality [1]. On the other hand, the SARS-CoV-2 pandemic has affected almost 27 million people worldwide [2]. Therefore, it is likely that many individuals with frailty get exposed to this novel virus. Some reports argued that frail individuals may develop more severe COVID-19 disease [3,4].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
Abstract The global COVID-19 pandemic has led to the rapid development of tests for detection of SARS-CoV-2. Studies are required to assess the relative performance of different assays. Here, we compared the performance of two commercial assays, the cobas® SARS-CoV-2 (Roche Diagnostics) and Xpert® Xpress SARS-CoV-2 (Cepheid®) tests, and a laboratory developed RT-PCR test adapted for use on the Hologic® Panther Fusion® (Hologic®) instrument as well as Bio-Rad and QIAGEN real-time PCR detection systems. Performance characteristics for each test were determined by testing clinical specimens an...
Source: Journal of Virological Methods - Category: Virology Authors: Tags: J Virol Methods Source Type: research
Christian Drosten returns to TWiV to provide an update on the COVID-19 situation in Germany, and general thoughts on testing, immunity, vaccines, therapeutics, epidemiology, reopening schools, and what will happen this fall. Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker Guest: Christian Drosten Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Christian previously on TWiV 601 Plague percolation phenomenon (Nature) TMPRSS2 inhibitor for SARS-CoV-2 (Cell) Repeated infections with endemic CoV (J Inf Dis) Koch Institute SAR...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
AbstractThe virology of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and the human immune response to the virus are under vigorous investigation. There are now several reports describing neurological symptoms in individuals who develop coronavirus disease 2019 (COVID-19), the syndrome associated with SARS-CoV-2 infection. The prevalence, incidence, and clinical course of these symptoms will become clearer in the coming months and years through epidemiological studies. However, the long-term neurological and cognitive consequence of SARS-CoV-2 infection will remain conjectural for some time and will likely r...
Source: Journal of NeuroVirology - Category: Neurology Source Type: research
THE 2019 CORONAVIRUS infectious disease (COVID-19), caused by the virus SARS-CoV-2, has resulted in the death of more 630,000 patients worldwide and has greatly impacted both medicine and society.1 Two main clinical manifestations in patients with COVID-19 are acute respiratory distress syndrome (ARDS) and thromboembolic events from an induced hypercoagulable state.2 In order to accommodate for surges in COVID-19 cases, medical centers across the globe have canceled or severely limited nonemergent surgical cases.
Source: Journal of Cardiothoracic and Vascular Anesthesia - Category: Anesthesiology Authors: Tags: Editorial Source Type: research
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