Tailoring haemophilia A prophylaxis with BAY 81-8973: A case series

Hemophilia A (HA) is a congenital bleeding disorder resulting from absence or deficiency of clotting factor VIII (FVIII). The symptoms consist of more or less severe hemorrhages as a result of trauma, surgical procedures, or spontaneous bleedings. These most likely occur into the joints (hemarthrosis) leading over the long term to progressive and irreversible hemophilic arthropathy, but bleeding may also occur into muscles, soft tissues and other sites (e.g. central nervous system) with potentially life-threatening consequences and, not least, drastic impairment in the individual's quality of life (QoL) [1].

Source: Transfusion and Apheresis Science - August 4, 2020 Category: Hematology Authors: Rita Carlotta Santoro, Gaetano Giuffrida, Filomena Daniele, Fabio Gagliano, Maria Francesca Mansueto, Valeria Calafiore, Sergio Siragusa, Mariasanta Napolitano Source Type: research