Antagonism of proNGF or its receptor p75 NTR reverses remodelling and improves bladder function in a mouse model of diabetic voiding dysfunction

Conclusions/interpretationOur findings indicate that blockade of proNGF and the p75NTR receptor in diabetes can impede the development and progression of DVD. The reported improvements in morphological and functional features in our DVD model validates the proNGF/p75NTR axis as a potential therapeutic target in this pathology.Graphical abstract

http://link.springer.com/10.1007/s00125-020-05222-4

Source: Diabetologia - August 12, 2020 Category: Endocrinology Source Type: research