Novel ex vivo disease model for extramammary Paget ’s disease using the cancer tissue-originated spheroid method

Extramammary Paget ’s disease (EMPD) is a rare cutaneous adenocarcinoma that was initially described in 1889 [1]. Clinically, EMPD presents as a well-circumscribed, erythematous plaque that is often eczematoid and ulcerated. EMPD frequently presents on the genitalia and perianal region in the elderly [2]. Histopatho logically, EMPD is characterized by the intraepidermal proliferation of Paget's cells, which are large cells with an abundant basophilic or amphophilic cytoplasm. The EMPD tumor cells can, with time, invade the dermis and metastasize to local lymph nodes and distant sites [3].

Source: Journal of Dermatological Science - August 4, 2020 Category: Dermatology Authors: Takahiro Arita, Jumpei Kondo, Yuka Kaneko, Miho Tsutsumi, Mai Kanemaru, Mari Matsui, Yukiyasu Arakawa, Norito Katoh, Masahiro Inoue, Jun Asai Source Type: research