Cancer-Associated Fibroblasts in Mycosis Fungoides Promote Tumor Cell Migration and Drug Resistance via CXCL12/CXCR4

This study sought to characterize CAFs in MF and their cross talk with the lymphoma cells using primary fibroblast cultures from punch biopsies of patients with early-stage MF and healthy subjects. MF cultures yielded significantly increased levels of FAP α, a CAF marker, and CAF-associated genes and proteins: CXCL12 (ligand of CXCR4 expressed on MF cells), collagen XI, and MMP2.

Source: Journal of Investigative Dermatology - August 10, 2020 Category: Dermatology Authors: Anna Aronovich, Lilach Moyal, Batia Gorovitz, Iris Amitay-Laish, Hadas Prag Naveh, Yaara Forer, Lea Maron, Jamal Knaneh, Dean Ad-El, Dafna Yaacobi, Eric Barel, Neta Erez, Emmilia Hodak Tags: Original Article Source Type: research