Cancers, Vol. 12, Pages 2171: Characterization of the DNAM-1, TIGIT and TACTILE Axis on Circulating NK, NKT-Like and T Cell Subsets in Patients with Acute Myeloid Leukemia
Conclusions: The expression of DNAM-1 is reduced in NK cells and in CD4+ and CD8+ T cells from AML patients compared with those from healthy volunteers. An increased percentage of NK and T cells lacking DNAM-1 and co-expressing TIGIT and TACTILE is associated with patient survival, supporting the role of TIGIT as a novel candidate for checkpoint blockade.
Source: Cancers - Category: Cancer & Oncology Authors: Isabel Valhondo Fakhri Hassouneh Nelson Lopez-Sejas Alejandra Pera Beatriz Sanchez-Correa Beatriz Guerrero Juan M. Bergua Maria Jose Arcos Helena Ba ñas Ignacio Casas-Avil és Joaquin Sanchez-Garcia Josefina Serrano Carmen Martin Esther Duran Corona Alon Tags: Article Source Type: research