Follow-up of Soluble Mesothelin-related Protein (SMRP) Levels in Subjects with Asbestos-related Disorders

Publication date: Available online 3 August 2020Source: Safety and Health at WorkAuthor(s): Eun-Kee Park, Anthony R. Johnson, Donald Wilson, Paul S. Thomas, Deborah H. Yates
Source: Safety and Health at Work - Category: Occupational Health Source Type: research

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We present a pooled cohort study on long-term mortality in exposed workers. METHODS: Pool of 43 Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding, glasswork, harbors, insulation and other industries). SMRs were computed by industrial sector for the 1970-2010 period, for the major causes, using reference rates by age, sex, region and calendar period. RESULTS: The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Asbestos exposure was estimated at the plant and period levels. Asbestos related mortality was significantly increase...
Source: Annali dell Istituto Superiore di Sanita - Category: General Medicine Tags: Ann Ist Super Sanita Source Type: research
This study will compare the effectiveness of the drug against a control group receiving only the gemcitabine and celecoxib. Patients have a one-in-two chance of being randomly assigned to either the adenovirus treatment or the control group. Adenovirus-delivered interferon Alpha-2b is designed as a second- or third-line treatment for patients who have failed in earlier regimens. Patients who previously had aggressive mesothelioma surgery but whose tumors have since progressed would be eligible to enroll. Success at the phase III level would mark the culmination of 20 years of researching and fine tuning gene therapy for us...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
British Journal of Cancer, Published online: 22 September 2020; doi:10.1038/s41416-020-01078-yStandards of care in mesothelioma treatment
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
Publication date: Available online 20 September 2020Source: Safety and Health at WorkAuthor(s): Dongmug Kang, Saemi Jung, Yun-Ji Kim, Juyoung Kim, Sangjun Choi, Se Yeong Kim, Youngki Kim
Source: Safety and Health at Work - Category: Occupational Health Source Type: research
Conclusions: The global mesothelioma burden, based on reported numbers, is currently shouldered predominantly by high-income countries; however, mesothelioma burdens will likely manifest soon in upper middle-income and eventually in low and lower middle-income countries.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Conclusions: BAPE is diagnosed by exclusion. A suspected diagnosis of BAPE with an asbestos exposure should be considered, especially with the presence of pleural plaques, and/or DPT, and rounded atelectasis. The MDT-based diagnostic approach may reduce misdiagnosis. PMID: 32944346 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
No abstract available
Source: Oncology Times - Category: Cancer & Oncology Tags: News Source Type: research
We present a case of bony metastasis from a rare histological subgroup of malignant pleural mesothelioma. The diagnosis was challenging; however, modern immunohistochemistry and molecular testing provided a diagnostic opportunity and potentially saved further unnecessary investigation. AbstractMalignant pleural mesothelioma (MPM) is an insidious primary neoplasm of the pleura that can be challenging to diagnose and is commonly considered to be only locally invasive. We present the case of a 74 ‐year‐old male who presented with clinical features of MPM but from whom pleural fluid and biopsies initially suggested benign ...
Source: Respirology Case Reports - Category: Respiratory Medicine Authors: Tags: Case Report Source Type: research
Publication date: Available online 16 September 2020Source: International Journal of Surgery Case ReportsAuthor(s): Margherita Cattaneo, Paolo Mendogni, Francesco Damarco, Davide Tosi
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
In this study, we found that the upregulation of Foxp3+ regulatory T cells (Tregs) in the mesothelioma tumor microenvironment after nonablative oligofractionated irradiation significantly limited the success of irradiation. Using DEREG mice, which allow conditional and efficient depletion of Foxp3+ Tregs by diphtheria toxin injection, we observed that transient Foxp3+ Treg depletion immediately after nonablative oligofractionated irradiation provided synergistic local control and biased the T cell repertoire toward central and effector memory T cells, resulting in long-term cure. Furthermore, this combination therapy showe...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
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