A Randomized Placebo-controlled Trial to Evaluate the Safety and Immunogenicitiy of the COVID-19 Vaccine

Condition:   COVID-19 Interventions:   Biological: Two COVID-19 vaccine candidate (TMV-083) administrations - Low dose;   Biological: Two COVID-19 vaccine candidate (TMV-083) administrations - High dose;   Biological: One COVID-19 vaccine candidate (TMV-083) administration - High dose;   Other: Placebo Sponsors:   Institut Pasteur;   Themis Bioscience GmbH;   Coalition for Epidemic Preparedness Innovations (CEPI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Jeffrey A. SingerSome observers of our policy toward the coronavirus pandemiccriticize the tendency to focus on case numbers alone, when hospitalization rates and fatality rates are what really matter. And as we learn more about the COVID virus, mitigation and treatment is improving and fatalities are diminishing.Similarly, the U.S. Department of Justice ’s policy toward the overdose epidemic seems to be focused on arrests and drug interdictions, apparent in a DOJpress release today, itemizing the arrests of drug traffickers and seizures of illegal drugs that have resulted since “Operation SOS&rd...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
We present advances in modeling techniques that have led to fundamental disease discoveries and impacted clinical translation.Recent FindingsCombining mechanistic models and machine learning algorithms has led to improvements in the treatment ofShigella and tuberculosis through the development of novel compounds. Modeling of the epidemic dynamics of malaria at the within-host and between-host level has afforded the development of more effective vaccination and antimalarial therapies. Similarly, in-host and host-host models have supported the development of new HIV treatment modalities and an improved understanding of the i...
Source: Current Pathobiology Reports - Category: Laboratory Medicine Source Type: research
(American Association for the Advancement of Science) Researchers who adapted standard epidemiological models to explore how the COVID-19 pandemic trajectory might unfold in the next five years report diverse scenarios ranging from recurring severe epidemics to elimination.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
r U Abstract For a long time, most of the infectious diseases seemed to have become under control. In particular, vaccinations have contributed to this development. In recent years newly occurring bacterial infections caused by multidrug-resistant pathogens and viral infections, such as the chikungunya virus, influenza epidemics and currently the COVID-19 pandemic, are endangering the world population. This specifically affects patients with rheumatological diseases, who often require immunosuppressive therapy and are thus at risk for infections. Vaccinations can protect those affected, both individually and ...
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
AbstractPurpose of ReviewCoronavirus disease 2019 (COVID-19) pandemic has major health and economic impacts. We review disease characteristics in children.Recent FindingsChildren comprise 1 –2% of the diagnosed cases, and typically suffer mild disease. The median age of infected children is 3.3–11 years, and male/female ratio is 1.15–1.55. Common symptoms in children include upper respiratory symptoms (26–54%), cough (44–54%), fever (32–65%), and gastrointestinal (15–30% ) symptoms. Substantial proportion (4–23%) are asymptomatic. Death rates are up to 0.7%. Risk factors...
Source: Current Infectious Disease Reports - Category: Infectious Diseases Source Type: research
i-Long Chen Some coronaviruses are zoonotic viruses of human and veterinary medical importance. The novel coronavirus, severe acute respiratory symptoms coronavirus 2 (SARS-CoV-2), associated with the current global pandemic, is characterized by pneumonia, lymphopenia, and a cytokine storm in humans that has caused catastrophic impacts on public health worldwide. Coronaviruses are known for their ability to evade innate immune surveillance exerted by the host during the early phase of infection. It is important to comprehensively investigate the interaction between highly pathogenic coronaviruses and their hosts. In th...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
The objective of this study was to describe the substitution frequency of the S and N proteins of SARS-CoV-2 in South America. A total of 504 amino acid and nucleotide sequences of the S and N proteins of SARS-CoV-2 from seven South American countries (Argentina, Brazil, Chile, Ecuador, Peru, Uruguay, and Colombia), reported as of June 3, and corresponding to samples collected between March and April 2020, were compared through substitution matrices using the Muscle algorithm in MEGA X. Forty-three sequences from 13 Colombian departments were obtained in this study using the Oxford Nanopore and Illumina MiSeq technologies,...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research
Coronavirus disease 2019 (COVID-19), an acute onset pneumonia caused by a novel Betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in the Wuhan City of China in December 2019 and evolved into a global pandemic. To date, there are no proven drugs or vaccines against this virus. Hence, the situation demands an urgent need to explore all potential therapeutic strategies that can be made available to prevent the disease progression and improve patient outcomes. In absence of clinically proven treatment guidelines, several repurposed drugs and investigational agents are currently being evalua...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Homœopathic Links 2020; 33: 171-179 DOI: 10.1055/s-0040-1715636Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus strain that has not been ever found in humans before December 2019. Both the coronavirus disease 2019 (COVID-19) case fatality rate and deaths per million population in the top 10 affected countries are increasing a lot due to ever-increasing number of new cases among countries facilitated by increased affinity of SARS-CoV-2 to bind human angiotensin-converting enzyme 2 (ACE2) receptors. While human-to-human transmission of SARS-CoV-2 happens through close contact with an in...
Source: Homoeopathic Links - Category: Complementary Medicine Authors: Tags: Review Article Source Type: research
Homœopathic Links 2020; 33: 222-227 DOI: 10.1055/s-0040-1714374The pandemic coronavirus disease 2019 (COVID-19) has become a public health emergency of international concern affecting human health and economy across the world. The outbreak in India is accelerating even after enforcement of lockdown as well as promotion of hand hygiene, respiratory etiquettes and social distancing mainly due to nonavailability of specific antiviral medicine and vaccine. Historically, for the purpose of prevention and treatment, homoeopathy has shown its usefulness in recent and past epidemics using carefully selected medicines as genu...
Source: Homoeopathic Links - Category: Complementary Medicine Authors: Tags: Perspective Source Type: research
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