An Aged Hematopoietic System can Cause Cognitive Decline via SASP Component CyPA
Today's open access paper outlines an investigation into how the aging of hematopoietic stem cell populations in bone marrow, responsible for producing blood and immune cells, can contribute to age-related dysfunction in the brain. The authors find that detrimental effects are mediated by circulating levels of CyPA, a signaling factor that is a part of the senescence-associated secretory phenotype (SASP), an inflammatory mix of signal molecules produced by senescent cells. The focus here is on direct inhibition of CyPA as an approach to therapy, but senolytic treatments to clear senescent cells may be the more useful approach if these errant cells are indeed the source of raised levels of CyPA. This seems reasonable, but is yet to be proven rigorously.
The aging of hematopoietic stem cells takes several forms. The population of functional stem cells declines due to damage, leading to a drop in the number of immune cells produced. This lack of reinforcements is one of the reasons why the aging immune system becomes dysfunctional, cluttered with exhausted, senescent, and malfunctioning cells. In addition, age-related changes in signaling and the stem cell niche in bone marrow cause detrimental changes in the distribution of types of immune cell produced. More myeloid cells and fewer lymphoid cells are produced, a change known as myeloid skew.
The aged hematopoietic system promotes hippocampal-dependent cognitive decline
In mice and humans, the hematopoiet...
Source: Fight Aging! - Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
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