Long-Term Negative Thinking Tied to Alzheimer Risk

TUESDAY, Aug. 4, 2020 -- Repetitive negative thinking (RNT) may be associated with increased Alzheimer disease (AD) risk, according to a study published in the July issue of Alzheimer's&Dementia. Natalie L. Marchant, Ph.D., from University...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news

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I recently collaborated on a review paper covering the history of clinical work on upregulation of nicotinamide adenine dinucleotide (NAD) as an approach to therapy. This is of interest to the aging research community because NAD is important to mitochondrial function. NAD levels diminish with age, alongside a loss of mitochondrial function that is known to contribute to the onset and progression of many age-related conditions. Animal studies and a few clinical trials have indicated that increased NAD levels may improve, for example, cardiovascular function in older individuals, as a result of improved mitochondrial functi...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
To coincide with World Alzheimer ’s Day, pain assessment app PainChek has published a new report on pain and dementia. 
Source: mobihealthnews - Category: Information Technology Source Type: news
Alzheimer's disease neuropathologies (amyloid- β and tau) frequently co-exist to varying degrees in Lewy body dementias (LBD), which include dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD).
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Review article Source Type: research
DEMENTIA symptoms include memory loss, difficulty concentrating, and having slower thoughts. But you could be raising your risk of Alzheimer's disease signs by sleeping in a certain way. Should you change your sleep position to protect against dementia?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Alzheimer ’s disease (AD) is a progressive, late-onset dementia with no effective treatment available. Recent studies suggest that AD pathology is driven by age-related changes in metabolism. Alterations in met...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Short report Source Type: research
ConclusionsModules of tightly regulated lipids and proteins, drivers in lipid homeostasis and innate immunity, are strongly associated with AD phenotypes.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In this study, new thiazolylhydrazone derivatives (2a–2l) were designed and synthesized based on the cholinergic hypothesis. Their chemical structures were confirmed by 1H NMR, 13C NMR, and HRMS spectrometric techniques. The ADME (absorption, distribution, metabolism, elimination) parameters of the synthesized compounds were predicted by using QikProp 4.8 software. It was concluded that all compounds presented satisfactory drug-like characteristics. Furthermore, their inhibitory activities against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro were also tested by modified the Ellman spectro...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Contributors : Haowei Jiang ; Morgan Newman ; Stephen Pederson ; Michael LardelliSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioAlzheimer ’s disease is the most common form of age-related dementia. At least 15 mutations in the human gene PRESENILIN 2 (PSEN2) have been found to cause familial Alzheimer’s disease (fAD). Zebrafish possess an orthologous gene, psen2, and present opportunities for investigation of PRESENILIN function r elated to Alzheimer’s disease. The most prevalent and best characterized fAD mutation in PSEN2 is N141I. The equivalent codon in zebrafish...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Danio rerio Source Type: research
People living with dementia are the only ones who really understand what it’s like to live with their form of the disease, whether it’s Alzheimer’s or another type such as frontotemporal (FTD) or Lewy body (LBD). Sadly, the ability to communicate becomes compromised by dementia. That being said, care partners can, if we take time to search out the meaning behind their words or actions, continue to improve the care provided. Here are some tips that can help you. View the entire slideshow on HealthCentral for insight into what your loved one with Alzheimer's wishes a careg...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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