Modulation of NADPH oxidase and Nrf2/HO ‐1 pathway by vanillin in cisplatin‐induced nephrotoxicity in rats

ConclusionsThe antioxidant mechanism by which vanillin protected against CP ‐induced nephrotoxicity involved the inhibition ofNOX ‐4 along with the stimulation of Nrf2/HO ‐1 signalling pathway. These in turn inhibited inflammation and apoptosis.

Source: Journal of Pharmacy and Pharmacology - August 2, 2020 Category: Drugs & Pharmacology Authors: Nahla N. Younis, Nehal M Elsherbiny, Mohamed A. Shaheen, Mohamed M. Elseweidy Tags: Research Paper Source Type: research