Cancers, Vol. 12, Pages 2160: The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis

Cancers, Vol. 12, Pages 2160: The Pathologic and Molecular Landscape of Esophageal Squamous Cell Carcinogenesis Cancers doi: 10.3390/cancers12082160 Authors: Gianluca Businello Paola Parente Luca Mastracci Gianmaria Pennelli Giulia Traverso Massimo Milione Elena Bellan Mauro Michelotto Andromachi Kotsafti Federica Grillo Matteo Fassan Esophageal squamous cell carcinoma represents the most common histotype of epithelial neoplasm occurring within esophageal mucosa worldwide. Despite the comprehensive molecular characterization of this entity, to date no significant targeted therapy has been introduced into clinical practice. In this review, we describe the molecular landscape of esophageal squamous cell carcinoma based on the most recent literature. Moreover, we focus on other rare variants and on the relationship with head and neck squamous cell carcinomas.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research