BRCA1/2 genes mutations, ovarian reserve and female reproductive outcomes: a systematic literature review.

BRCA1/2 genes mutations, ovarian reserve and female reproductive outcomes: a systematic literature review. Minerva Ginecol. 2020 Aug 03;: Authors: Merlino L, Chiné A, Galli C, Piccioni MG Abstract BRCA1 and BRCA2 genes mutations seems to impact female fertility, in addition to increasing the risk of ovarian and breast cancer. Several studies had investigated this issue but data available are still controversial. In order to clarify the role of BRCA1 and BRCA2 mutations in female fertility and ovarian function we carried out a systematic review of the literature with the aim to establish a possible management's strategy of these patients. A review of current literature regarding BRCA mutation (BRCAm) and fertility was conducted using the PubMed tool to select remarkable articles with the keywords ''BRCA1/2 gene', "BRCA1/2 mutation", ''anti-Mullerian hormone'', ''female fertility'', ''ovarian reserve'' and ''premature ovarian failure''. In current literature there are controversial findings about the relation between BRCA genes mutations and lifespan of female reproductive age. Several studies showed an higher risk of premature ovarian insufficiency of BRCAs mutations carriers, according to lower serum AMH level, primordial follicle count, or fewer oocyte yield after ovarian stimulation; on the other hand more recent studies reported not significant differences in serum AMH level or in reproductive outcomes between mutated and non-mut...
Source: Minerva Ginecologica - Category: OBGYN Tags: Minerva Ginecol Source Type: research