Accelerated Differentiation of Human Pluripotent Stem Cells into Neural Lineages via an Early Intermediate Ectoderm Population

This study describes that inhibiting selected signaling pathways enables the immediate exit from pluripotency and converts the stem cells within 24  hours into precursor cells that can be rapidly directed to generate desired neural populations desirable for research and potential cell therapies. This work removes a historical bottleneck that has prevented improving the control and speed of making neural cells from hPSCs and will likely change the way human neurons are generated in the future.

Source: Stem Cells - August 2, 2020 Category: Stem Cells Authors: Patrick Walsh, Vincent Truong, Sushmita Nayak, Marietta Sald ías Montivero, Walter C. Low, Ann M. Parr, James R. Dutton Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research