Discovery of a novel selective water-soluble SMAD3 inhibitor as an antitumor agent.

This study not only provided a preferable lead compound, 16d, for further drug discovery or a potential tool to study SMAD3 biology, but also proved the effectiveness of our strategy for water-solubility driven optimization.
PMID: 32738967 [PubMed - in process]

Source: Bioorganic and Medicinal Chemistry Letters - August 4, 2020 Category: Chemistry Authors: Wu N, Lian G, Sheng J, Wu D, Yu X, Lan H, Hu W, Yang Z Tags: Bioorg Med Chem Lett Source Type: research