The Potential of Corticospinal-Motoneuronal Plasticity for Recovery after Spinal Cord Injury
AbstractPurpose of ReviewThis review focuses on a relatively new neuromodulation method where transcranial magnetic stimulation over the primary motor cortex is paired with transcutaneous electrical stimulation over a peripheral nerve to induce plasticity at corticospinal-motoneuronal synapses.Recent FindingsRecovery of sensorimotor function after spinal cord injury largely depends on transmission in the corticospinal pathway. Significantly damaged corticospinal axons fail to regenerate and participate in functional recovery. Transmission in residual corticospinal axons can be assessed using non-invasive transcranial magnetic stimulation which, when combined at the proper time with peripheral nerve electrical stimulation, can be used to improve voluntary motor output, as was recently demonstrated in clinical studies in humans with chronic incomplete spinal cord injury. These two stimuli are applied at precise inter-stimulus intervals to reinforce corticospinal synaptic transmission using principles of spike-timing-dependent plasticity.SummaryWe discuss the neural mechanisms and application of this neuromodulation technique and its potential therapeutic effect on the recovery of function in humans with chronic spinal cord injury.
Publication date: Available online 28 September 2020Source: Brain, Behavior, and ImmunityAuthor(s): Jesús Amo-Aparicio, Alba Sanchez-Fernandez, Suzhao Li, Elan Z. Eisenmesser, Cecilia Garlanda, Charles A. Dinarello, Ruben Lopez-Vales
Authors: Hassaballa D, Harvey RL Abstract The management of pain in persons with neurological injuries is challenging and complex. A holistic view and clinical approach are necessary when addressing pain in patients with neurological impairment because interpreting signs and symptoms and deciphering sources of pain is never a straightforward process. This problem is further magnified with the management of central pain syndromes. The best approach is to have a good understanding of the clinical characteristics commonly found in this patient population, in particular for patients with stroke, multiple sclerosis (MS)...
We describe pain intensity and interference at baseline and 1 year postinjury in burn, traumatic brain injury (TBI), and spinal cord injury (SCI) survivors and compare them with the general population (GP). We tested a custom Patient Reported Outcomes Measurement Information System (PROMIS) pain interference short form developed for use in trauma populations. METHODS We administered a pain intensity numerical rating scale and custom PROMIS pain interference short forms at baseline and/or 1 year postinjury from participants (≥18 years) at three Model System projects (burn, TBI, and SCI). Scores were compared across in...
Conclusions: The biomembrane barrier formed at the tumor edge after RFA can prevent bone cement leakage into the spinal canal, reducing spinal cord injury and prolonging the survival time.
Condition: Spinal Cord Injury at C5-C7 Level Interventions: Other: FES+CBA; Other: FES Sponsor: Azienda Ospedaliero, Universitaria Pisana Completed
Elezanumab (ABT-555) is an investigational treatment being evaluated in neurological disorders, including treatment following spinal cord injury Orphan Drug Designation is given to a drug or biologic for the treatment, diagnosis or prevention of a rare ... Biopharmaceuticals, Neurology, FDA AbbVie, elezanumab, spinal cord injury
To evaluate the incidence and epidemiological characteristics of acquired nontraumatic spinal cord injury (NTSCI) in Finland.
Authors: Liao YX, He SS, He ZM Abstract Transient paralysis following spinal decompression surgery is a rare but devastating postoperative complication. Spinal cord ischemia-reperfusion injury has been identified as one of the crucial pathogenic factors contributing to the sudden neurological deterioration associated with spinal decompression surgery. 'White cord syndrome' is a characteristic imaging manifestation of spinal cord ischemia-reperfusion injury, referring to high intramedullary signal changes in the sagittal T2-weighted MRI scan with unexplained neurological deficits following surgical decompression. Th...
CONCLUSION: In our study, 70% of the muscles with a SMMT motor response of zero and 72% of the muscles with a SMMT motor response greater than or equal to one demonstrated SA on EMG. The use of the SMMT as a clinical measure to differentiate LMN from UMN integrity may be limited when applied. PMID: 32972329 [PubMed - as supplied by publisher]
Publication date: Available online 25 September 2020Source: Physiology &BehaviorAuthor(s): Zahra Behroozi, Fatemeh Ramezani, Atousa Janzadeh, Behnaz Rahimi, Farinaz Nasirinezhad