Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice
Publication date: Available online 2 August 2020Source: Brain, Behavior, and ImmunityAuthor(s): Andrea Du Preez, Diletta Onorato, Inez Eiben, Ksenia Musaelyan, Martin Egeland, Patricia A. Zunszain, Cathy Fernandes, Sandrine Thuret, Carmine M. Pariante
Publication date: November–December 2020Source: Heart &Lung, Volume 49, Issue 6Author(s): Linda Clements, Susan K. Frazier, Debra K. Moser, Terry A. Lennie, Misook L. Chung
Publication date: 1 January 2021Source: Personality and Individual Differences, Volume 168Author(s): Feizhong Zheng, Wenting Wu, Lijing Wang, Arlette J. Ngoubene-Atioky, Li Chen
CONCLUSION: In a NHP ARS model, sargramostim administered starting at 48 h post-radiation was effective to improve survival, while beneficial hematological effects were observed with sargramostim initiated up to 120 h post exposure. PMID: 32960660 [PubMed - as supplied by publisher]
In 2019, before the pandemic hit, nearly 1 in 5 adults had depression and nearly 1 in 6 had anxiety, with dramatic increases seen in 2020.Medscape Medical News
Authors: Ormel J, Bosker FJ, Hollon SD, Ruhe HG PMID: 32951616 [PubMed - as supplied by publisher]
This study aims at testing in a RCT the effectiveness of a disorder-specific, Internet-delivered CBT (ICBT) intervention for AjD. Participants were randomly allocated to either an ICBT with brief weekly telephone support (n=34) or a waiting list group (n=34). Beck's inventories for depression and anxiety were used as primary outcomes. The secondary outcomes were adjustment disorder symptoms, posttraumatic growth, positive and negative affect, and quality of life. In all, 76.5% of the participants completed the intervention. Compared to the control group, participants in the intervention condition showed significantly great...
We examined the association between androgen deprivation therapy (ADT) use and the risk of mild cognitive impairment (MCI) among prostate cancer patients. METHODS: We included 241 cognitively unimpaired men, aged 70 to 90, with a history of prostate cancer before enrollment in the population-based Mayo Clinic Study of Aging. Using the Rochester Epidemiology Project medical records-linkage system, ADT use and length of exposure were abstracted. Follow-up visits occurred every 15 months and MCI diagnoses were made based on clinical consensus. Cox proportional hazards models, with age as the timescale, were used to examin...
CONCLUSION: Never-married status above the mean first marriage age was associated with mental disorders and suicidality. These findings suggest the need for a national strategy to develop an environment where people with never-married status do not suffer even if their marriage is delayed. PMID: 32959544 [PubMed - in process]
Conditions: Depression; Anxiety; Suicidal Ideation; Substance Use Intervention: Behavioral: Knowing Who You Are (Becoming): Cultural Identity Intervention Sponsors: University of Alaska Anchorage; National Institute of General Medical Sciences (NIGMS) Enrolling by invitation
Conditions: Mild Traumatic Brain Injury; Internet-Delivered Cognitive Behavioural Therapy; Depression; Anxiety Intervention: Behavioral: Internet-delivered Cognitive Behavioural Therapy(ICBT) Sponsor: Lawson Health Research Institute Not yet recruiting