In Rare Cases, Diabetes & Cholesterol Drug Combo Could Be Toxic

MONDAY, Aug. 3, 2020 -- Taking the statin Crestor in combination with the diabetes drug canagliflozin (Invokana) may have the potential to trigger statin toxicity, a new case report suggests. Although this report details the problem in just one...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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Diabetes Metab. 2021 Sep 19:101284. doi: 10.1016/j.diabet.2021.101284. Online ahead of print.ABSTRACTAIM: Dyslipidaemia in type 2 diabetes mellitus (T2DM), which increases cardiovascular risk, includes abnormal metabolism of low-density lipoproteins (LDL). Our group has recently shown that liraglutide increases LDL catabolism in patients with T2DM and that it reduces the expression of PCSK9 (a major inhibitor of LDL-receptor expression) in vitro and in mice. This prompted us to study the effect of liraglutide on plasma PCSK9 level in patients with T2DM.METHODS: We studied prospectively 82 patients with T2DM (51 without sta...
Source: Diabetes and Metabolism - Category: Endocrinology Authors: Source Type: research
Conclusions. Selected statins, FLC, CAs and HMGA can manage or have a potential to manage at least three features of the cluster of seven. Most of the literature-stated concerns are with select statins but there are concerns (one actual and two potential) with HMGA.PMID:34523296 | DOI:10.2478/enr-2021-0020
Source: Endocrine Regulations - Category: Endocrinology Authors: Source Type: research
CONCLUSIONS: This study suggests that there are differences in the diabetogenic effect of statins. Simvastatin and high doses of atorvastatin may be associated with greater impairment in glucose metabolism than pitavastatin and other statins with less lipid-lowering potency such as pravastatin.PMID:34517987 | DOI:10.1016/j.medcli.2021.06.018
Source: Medicina Clinica - Category: General Medicine Authors: Source Type: research
CONCLUSIONS: LDL-C control is suboptimal and the available LLT armamentarium, most importantly combination therapy, is being underutilized in high/very high risk patients leading to inadequate management of cardiovascular risk.PMID:34517739 | DOI:10.1080/03007995.2021.1973396
Source: Current Medical Research and Opinion - Category: Research Authors: Source Type: research
CONCLUSIONS: This study suggests that there are differences in the diabetogenic effect of statins. Simvastatin and high doses of atorvastatin may be associated with greater impairment in glucose metabolism than pitavastatin and other statins with less lipid-lowering potency such as pravastatin.PMID:34517987 | DOI:10.1016/j.medcli.2021.06.018
Source: Medicina Clinica - Category: General Medicine Authors: Source Type: research
AbstractPurpose of ReviewHypertriglyceridemia (HTG) is common and is a significant contributor to atherosclerosis and pancreatitis risk. Specific HTG treatments have had variable success in reducing atherosclerosis risk. Novel therapies for severe HTG treatment and pancreatitis risk reduction are likely to be available soon. These novel therapies are expected to have broader applications for more moderate HTG and atherosclerosis risk reduction as well.Recent FindingsNHANES 2012 data has confirmed a reduction in average triglyceride (TG) levels in the US population. Dietary modification and weight reduction when needed rema...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: Compared with atorvastatin and rosuvastatin, pitavastatin might be associated with a lower risk of safety events in Asians.PMID:34497171 | DOI:10.5551/jat.63076
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Authors: Source Type: research
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