Immune monitoring of a child with autoimmune hepatitis and type 1 diabetes during COVID-19 infection

We present the unique opportunity we had to monitor the liver, IL-6 and immune cell course before, during and after COVID-19 in a boy with autoimmune hepatitis (AIH) and type 1 diabetes (T1D). CD4+ and CD8+ T cells frequencies decreased because of prednisolone, followed by a plateauing increase whereas CD19+CD20+ B cell increased strongly and was unaffected by COVID-19 infection. Moreover, the percentage of activated CD8+ T cells expressing HLA-DR (CD8+HLA-DR+) increased during COVID-19 and subsided after its clearance. Total regulatory T cells (Tregs: CD4+CD25+CD127lowFOXP3+) remained stable. Although activated Tregs (CD4+CD45RA-FOXP3high) strongly increased upon prednisolone, it decreased afterwards. Furthermore, regulatory B cells (Bregs: CD19+CD20+CD24highCD38high) declined sharply owing to prednisolone. Serum IL-6 remained undetectable at all times. We demonstrated for the first time immune monitoring in a child with AIH and T1D before, during and after COVID-19. We hypothesize that continuing with low level of prednisolone without azathioprine may have abrogated activated Tregs, Bregs and IL-6 production and therefore permitting the activation of CD8+ T cells, clearing the virus.
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Case Reports Source Type: research

Related Links:

Authors: Lam UN, Siddik NSFMM, Yussof SJM, Ilenghoven D, Ibrahim S PMID: 32971604 [PubMed]
Source: Archives of Plastic Surgery - Category: Cosmetic Surgery Tags: Arch Plast Surg Source Type: research
In this report, we describe the case of a SARS-CoV-2 infection (COVID-19) in an infant with mild fever and diarrhea in the absence of respiratory distress. A 45-day-old male infant with COVID-19 was transferred to our pediatric department. He had mild fever and diarrhea at admission. Positive-to-negative nasal swab conversion occurred on the 21st day from the onset of symptoms. However, stool swab positivity persisted during the 6-week admission period and for 7 weeks during follow-up at an outpatient clinic after discharge. Negative conversion in a stool specimen occurred on the 142nd day from the onset of symptoms. This ...
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
In conclusion, gut inflammation associated with chronic colitis does not mediate a further increase in the cellular entry of SARS-CoV-2. PMID: 32975064 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
PMID: 32976369 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Authors: Uvais NA, Rasmina V PMID: 32975917 [PubMed - as supplied by publisher]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Conclusions: "Home staying syndrome" is an undefined syndrome of unusual symptoms of abnormal sleep (altering sleep time and duration) and frequent urination> 3 times/hour. This syndrome is associated with staying at home for a long period of time and is easily resolved by doing any activity such as sports or visiting friends. While this syndrome is rare, it may be more prevalent now due to the COVID-19 pandemic, which forces people to stay home for infection prevention. PMID: 32975916 [PubMed - as supplied by publisher]
Source: The Primary Care Companion for CNS Disorders - Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Abstract Without a nationwide strategy or infrastructure, we've missed a chance to control the pandemic. PMID: 32976142 [PubMed - as supplied by publisher]
Source: The American Journal of Nursing - Category: Nursing Authors: Tags: Am J Nurs Source Type: research
Authors: Abstract The pandemic has stretched resources and complicated the delivery of care. PMID: 32976135 [PubMed - as supplied by publisher]
Source: The American Journal of Nursing - Category: Nursing Tags: Am J Nurs Source Type: research
Authors: PMID: 32976133 [PubMed - as supplied by publisher]
Source: The American Journal of Nursing - Category: Nursing Tags: Am J Nurs Source Type: research
Authors: Abstract Many challenges lie ahead, including public acceptance. PMID: 32976132 [PubMed - as supplied by publisher]
Source: The American Journal of Nursing - Category: Nursing Tags: Am J Nurs Source Type: research
More News: Children | Coronavirus | COVID-19 | Diabetes | Diabetes Type 1 | Endocrinology | Gastroenterology | Hepatitis | Liver | Prednisolone | Urology & Nephrology