Risk factors for endoscopic severity of diverticular disease of the colon and its outcome: a real-life case-control study
Conclusions Several factors are associated with the severity of diverticular disease according to the DICA classification. The DICA classification is also predictive of the outcome of the disease in terms of hospital admission, stay and costs.
Publication date: Available online 24 September 2020Source: Journal of Theoretical BiologyAuthor(s): Roberta Coletti, Andrea Pugliese, Luca Marchetti
Publication date: Available online 24 September 2020Source: Advances in Biological RegulationAuthor(s): Nilufar Rahimova, Mariana Cooke, Suli Zhang, Martin J. Baker, Marcelo G. Kazanietz
Publication date: Available online 24 September 2020Source: Microvascular ResearchAuthor(s): Lauren Van Hove, Kirsten R. Kim, Denise M. Arrick, William G. Mayhan
Publication date: Available online 24 September 2020Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): Aurélie H. Benfield, Sira Defaus, Nicole Lawrence, Stephanie Chaousis, Nicholas Condon, Olivier Cheneval, Yen-Hua Huang, Lai Yue Chan, David Andreu, David J. Craik, Sónia Troeira Henriques
Abstract Endometrial cancer (EC) harboring heterozygous POLE proofreading inactivating mutations (POLE-exo*) is associated with an increased number of somatic mutations that result in a distinctive anti-tumor immune response. However, the consequences of such POLE mutations in the context of the missing wild-type allele have not yet been described in endometrial tumors. A 72-year-old woman harboring a germline monoallelic frameshift mutation (p.Pro269fsTer26) in POLE was diagnosed with an EC having a somatic heterozygous mutation in the exonuclease domain of POLE (S459F). Targeted gene sequencing revealed an ultramutated p...
CONCLUSION: The study identified both a high prevalence of xerostomia regardless of the chemotherapy used and the need to create protocols to improve the quality of life of these patients. PMID: 32965427 [PubMed - in process]
Publication date: Available online 25 September 2020Source: Actas Urológicas Españolas (English Edition)Author(s): L. Polanco Pujol, F. Herranz Amo, J. Caño Velasco, M. Moralejo Garate, D. Subirá Rios, G. Barbas Bernardos, J. Mayor de Castro, J. Aragón Chamizo, A. Husilllos Alonso, C. Hernández Fernández
Publication date: Available online 24 September 2020Source: European UrologyAuthor(s): Vignesh T. Packiam, Bimal Bhindi
BY ALEJANDRO E. MACIAS; BILLY ZHANG; KRISTEN HUGHES; SHAMIM KHAN, MD; FRANCISCO JACOME, MDA 73-year-old man with a past medical history of hypertension, type 2 diabetes, and hyperlipidemia and a surgical history for a coronary artery bypass presented with sudden, severe lower abdominal pain. He characterized his pain as 8/10 and was tender to palpation.Laboratory studies showed a white blood cell count of 7.51 with a glucose of 759, no bands, a platelet count of 230,000, and a lactic acid level of 6.7. Urinalysis showed +5 ketones and a glucose count of greater than 500. An abdominal CT showed possible microperforations...
BACKGROUND: Patients with liver disease face significant risk of complications and death when considering elective colorectal resection for benign or malignant indications. OBJECTIVE: We sought to determine the relationship between Model of End-Stage Liver Disease score and 30-day outcomes in patients undergoing elective colorectal resections. DESIGN: This was a retrospective cohort study. SETTINGS: The study included hospitals participating in the National Surgical Quality Improvement Program. PATIENTS: Adult patients who underwent elective colorectal resection from 2005 to 2011 were identified from the National Surgical ...