Evaluation of 11C-NR2B-SMe and Its Enantiomers as PET Radioligands for Imaging the NR2B Subunit Within the NMDA Receptor Complex in Rats

Conclusion: 11C-(S)-NR2B-SMe has adequate NR2B-specific PET signal in rat brain to warrant further evaluation in higher species. TC1 and SA4503 likely have off-target binding to NR2B in vivo.

Source: Journal of Nuclear Medicine - August 2, 2020 Category: Nuclear Medicine Authors: Cai, L., Liow, J.-S., Morse, C. L., Telu, S., Davies, R., Frankland, M. P., Zoghbi, S. S., Cheng, K., Hall, M. D., Innis, R. B., Pike, V. W. Tags: Basic Source Type: research