Radiation Dosimetry and Biodistribution of 68Ga-FAPI-46 PET Imaging in Cancer Patients

Conclusion: 68Ga-FAPI-46 PET/CT has a favorable dosimetry profile, with an estimated whole-body dose of 5.3 mSv for an administration of 200 MBq (5.4 mCi) of 68Ga-FAPI-46 (1.56 ± 0.26 mSv from the PET tracer and 3.7 mSv from 1 low-dose CT scan). The biodistribution study showed high TBRs increasing over time, suggesting high diagnostic performance and favorable tracer kinetics for potential therapeutic applications.

Source: Journal of Nuclear Medicine - August 2, 2020 Category: Nuclear Medicine Authors: Meyer, C., Dahlbom, M., Lindner, T., Vauclin, S., Mona, C., Slavik, R., Czernin, J., Haberkorn, U., Calais, J. Tags: Clinical Source Type: research