Drug discovery: First rational strategy to find molecular glue degraders

(CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences) Targeted protein degradation (TPD) represents a novel paradigm in drug discovery that could lead to more efficient medicines to treat diseases such as cancer. " Molecular glue degrader " are an emerging but understudied class of small molecules that have been shown to induce degradation of proteins commonly considered " undruggable " . CeMM Researchers have described a strategy that, for the first time, enables the rational and highly scalable discovery of novel molecular glue degraders.
Source: EurekAlert! - Biology - Category: Biology Source Type: news