An up-to-date catalogue of urinary markers for the management of prostate cancer

Purpose of review Prostate cancer (PCa) is the most commonly diagnosed cancer in men. Poor specificity and sensitivity of total PSA often results in over and sometimes underdetection/treatment. Therefore, more specific and sensitive biomarkers for the detection and monitoring especially of clinically significant PCa as well as treatment-specific markers are much sought after. In this field, urine has emerged as a promising noninvasive source of biomarkers. Recent findings RNA-based biomarkers are the most extensively studied type of urinary nucleic acids. ERG-Score/MiPS (Mi-Prostate Score) and SelectMDx might be considered as additional parameters together with clinical and imaging modalities to decrease unnecessary biopsies. miR Sentinel Tests could make it possible to accurately detect the presence of cancer and to distinguish low-grade from high-grade disease. In men with previous negative biopsies, PCA3 may suggest the need to repeat biopsy. Summary The definitive role of these markers and their clinical benefit needs future validation.
Source: Current Opinion in Urology - Category: Urology & Nephrology Tags: CONTROVERSIES IN UROLOGY: Edited by Shahrokh F. Shariat Source Type: research

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Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Condition:   Prostate Cancer Intervention:   Radiation: Stereotactic Body Radiotherapy Sponsor:   Linda Chan, MD Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
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Source: Roche Media News - Category: Pharmaceuticals Source Type: news
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Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
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Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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