Microstructural changes in the reward system are associated with post-stroke depression

Publication date: Available online 22 July 2020Source: NeuroImage: ClinicalAuthor(s): Lena KL Oestreich, Paul Wright, Michael J O'Sullivan
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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Conditions:   Stroke;   CVA (Cerebrovascular Accident);   Anxiety;   Depression Intervention:   Behavioral: Helping Ease Anxiety and Depression following Stroke Sponsor:   Glasgow Caledonian University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Antipsychotics are approved and prescribed to treat various conditions such as schizophrenia, mania, major depressive disorder, agitation, delusional disorder, psychosis, and Tourette's syndrome1. The haloperidol prescribing information2 in the United States (US) does not warn about the risk of stroke but has a black box warning for an increased risk of death among elderly patients with dementia-related psychosis treated with antipsychotic drugs. Nonetheless, antipsychotics are used for indications such as neuropsychiatric symptoms of dementia, in the presence or absence of psychosis; such use is not approved by the Food a...
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Source Type: research
CONCLUSION: Post-stroke depressive symptoms form a complex and multifactorial problem. Treatment outcome is influenced by the characteristics of the stroke, the patient, and their spouse. The results show that psychological distress is probably no obstacle to attempting to improve participation. The personalized predictions (prognostic index scores) of treatment outcome show promising results, which, after further replication and validation, could aid clinicians with treatment selection. PMID: 32965505 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - Category: Rehabilitation Tags: J Rehabil Med Source Type: research
Conclusions: This intervention can be feasible to administer as a home-based intervention and may help to alleviate language and neuropsychological complaints after stroke in low-literate or mixed-cultural populations. Further, large sample size studies are recommended.
Source: Annals of Indian Academy of Neurology - Category: Neurology Authors: Source Type: research
ConclusionThe results suggest that lysine, phenylalanine, threonine, and alanine intake is important for the maintenance of cognitive function in older people, independent of total protein intake.
Source: The Journal of Nutrition, Health and Aging - Category: Nutrition Source Type: research
Overkill: When Modern Medicine Goes Too Far by Paul Offit M.D.I am admittedly a huge fanboy of Paul Offit, an infectious disease guru at Children's Hospital of Philadelphia, one of the preeminent pediatric hospitals in the world. His latest bookOverall: When Modern Medicine Goes Too Far, is a collection of medical facts that are already known to the well-read individual, but fly in the face of wrongly-held, out-dated, commonly-believed medical concepts. The majority of the incorrect information was previously considered the standard of care, but newer and better science and studies have clearly demonstrated ...
Source: A Pediatrician's Blog - Category: Pediatrics Source Type: blogs
CONCLUSIONS: We identified no significant differences in C-FIM outcomes (gain, efficiency and effectiveness) either in LOS between PWA and patients without aphasia, though C-FIM differences were significant at admission and discharge. Aphasia was a significant predictor of C-FIM gain and C-FIM at discharge. PMID: 32967590 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - Category: Neurology Authors: Tags: Top Stroke Rehabil Source Type: research
Conditions:   SARS-CoV-2;   Post-stroke Depression;   Anxiety and Fear Intervention:   Sponsor:   Fatih Sultan Mehmet Training and Research Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This thesis aimed to elucidate the role of informal caregiver subjective well-being in explaining formal long-term care service (LTCS) use. A systematic review and meta-analysis of literature found that elevated caregiver burden, caregiver depression, and poorer caregiver health status are associated with increased formal LTCS use. Quantitative analyses of longitudinal data collected from stroke survivors and their caregivers revealed that increased caregiving burden and caregiver depression are prospective and concurrent predictors of stroke rehabilitation use at 12-month post-stroke, and that non-distressed caregivers at...
Source: International Journal of Integrated Care - Category: Nursing Source Type: research
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