Alterations in Power Spectral Density in Motor- and Pain-related Networks on Neuropathic Pain after Spinal Cord Injury

Publication date: Available online 25 July 2020Source: NeuroImage: ClinicalAuthor(s): Eunhee Park, Hyunsil Cha, Eunji Kim, Yu-Sun Min, Ae Ryoung Kim, Hui Joong Lee, Tae-Du Jung, Yongmin Chang
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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Authors: Hassaballa D, Harvey RL Abstract The management of pain in persons with neurological injuries is challenging and complex. A holistic view and clinical approach are necessary when addressing pain in patients with neurological impairment because interpreting signs and symptoms and deciphering sources of pain is never a straightforward process. This problem is further magnified with the management of central pain syndromes. The best approach is to have a good understanding of the clinical characteristics commonly found in this patient population, in particular for patients with stroke, multiple sclerosis (MS)...
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
We describe pain intensity and interference at baseline and 1 year postinjury in burn, traumatic brain injury (TBI), and spinal cord injury (SCI) survivors and compare them with the general population (GP). We tested a custom Patient Reported Outcomes Measurement Information System (PROMIS) pain interference short form developed for use in trauma populations. METHODS We administered a pain intensity numerical rating scale and custom PROMIS pain interference short forms at baseline and/or 1 year postinjury from participants (≥18 years) at three Model System projects (burn, TBI, and SCI). Scores were compared across in...
Source: Journal of Trauma and Acute Care Surgery - Category: Surgery Tags: BRIEF REPORTS Source Type: research
Authors: Liao YX, He SS, He ZM Abstract Transient paralysis following spinal decompression surgery is a rare but devastating postoperative complication. Spinal cord ischemia-reperfusion injury has been identified as one of the crucial pathogenic factors contributing to the sudden neurological deterioration associated with spinal decompression surgery. 'White cord syndrome' is a characteristic imaging manifestation of spinal cord ischemia-reperfusion injury, referring to high intramedullary signal changes in the sagittal T2-weighted MRI scan with unexplained neurological deficits following surgical decompression. Th...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Publication date: Available online 25 September 2020Source: Physiology &BehaviorAuthor(s): Zahra Behroozi, Fatemeh Ramezani, Atousa Janzadeh, Behnaz Rahimi, Farinaz Nasirinezhad
Source: Physiology and Behavior - Category: Physiology Source Type: research
Abstract A major portion of individuals affected by traumatic spinal cord injury (SCI) experience one or more types of chronic neuropathic pain (NP), which is often intractable to currently available treatments. The availability of reliable behavioral assays in pre-clinical models of SCI-induced NP is therefore critical to assess the efficacy of new potential therapies. Commonly used assays to evaluate NP-related behavior in rodents, such as Hargreaves thermal and von Frey mechanical testing, rely on the withdrawal response to an evoked stimulus. However, other assays that test spontaneous/non-evoked NP-related be...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research
Authors: Afshari K, Dehdashtian A, Haddad NS, Jazaeri SZ, Ursu DC, Khalilzadeh M, Haj-Mirzaian A, Shakiba S, Burns TC, Tavangar SM, Ghasemi M, Dehpour AR Abstract OBJECTIVES: To investigate the therapeutic effects of sumatriptan in a rat model of spinal cord injury (SCI) and possible anti-inflammatory and analgesic mechanisms underlying this effect. METHODS: Using an aneurysm mini-clip model of contusive SCI, T9-10 laminectomies were performed for 60 male rats. Animals were divided into six experimental groups (n = 10 per group) as follows: a minocycline administered positive control group, a saline-vehicl...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Conclusions: The discovery of the effect of SIRT1 on neuropathic pain in the VTA represents an important step forward in understanding the analgesic mechanisms of the VTA-NAc pathway. PMID: 32922581 [PubMed - in process]
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
This report provides a basis for addressing the therapeutic relevance of oxytocin as a potential preemptive analgesic molecule.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
This study investigated whether inhibiting spinal sPLA2 at the time of nerve root compression (NRC) modulates the pain, dorsal horn hyperexcitability, and spinal genes involved in glutamate signaling, nociception, and inflammation that are seen early after injury. Rats underwent a painful C7 NRC injury with immediate intrathecal administration of the sPLA2 inhibitor thioetheramide-phosphorlycholine. Additional groups underwent either injury alone or sham surgery. One day after injury, behavioral sensitivity, spinal neuronal excitability, and spinal cord gene expression for glutamate receptors (mGluR5 and NR1) and transport...
Source: NeuroReport - Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
In conclusion, HFSCS treatment attenuated SNI-induced neuropathic pain and partially restored the altered glutamate uptake after SNI. PMID: 32937185 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
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