Xanthone ‐enriched fraction of Garcinia mangostana and α‐mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion rats

ConclusionsHowever, α‐MG (50 mg/kg) and XEFGM (100 mg/kg) reversed the cognitive impairment induced by CCH in MWM test. α‐MG (50 mg/kg) was further tested upon sub‐acute 14‐day treatment in CCH rats. Cognitive improvement was shown in MWM test but not in long‐term potentiation (LTP). BDNF but not CaMKII was found to be down‐regulated in CCH rats; however, both parameters were not affected by α‐MG. In conclusion, α‐MG ameliorated learning and memory deficits in both acute and sub‐acute treatments in CCH rats by improving the spatial learning but not hippocampal LTP. Hence, α‐MG may be a promising lead compound for CCH‐associated neurodegenerative diseases, including vascular dementia and Alzheimer's disease.
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Research Paper Source Type: research