COVID-19 pneumonia: increased choline uptake with 18F-choline PET/CT

Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research

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Conclusions: As postoperative mortality in case of COVID pneumonia is not negligible, meticulous rules (precise triage, safe hospital path, high level of protection for health-care teams, prompt diagnosis of suspicious symptoms) should be strictly followed in patients undergoing CS during COVID pandemic. The role of therapies alternative to CS should be further assessed.
Source: Annals of Surgery - Category: Surgery Tags: COVID PAPERS Source Type: research
It is currently believed that innate immunity is unable to prevent the spread of SARS-CoV-2 from the upper airways to the alveoli of high-risk groups of patients. SARS-CoV-2 replication in ACE-2-expressing pneumocytes can drive the diffuse alveolar injury through the cytokine storm and immunothrombosis by upregulating the transcription of chemokine/cytokines, unlike several other respiratory viruses. Here we report histopathology data obtained in post-mortem lung biopsies of COVID-19, showing the increased density of perivascular and septal mast cells (MCs) and IL-4-expressing cells (n = 6), in contrast to the numbers foun...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Authors: Troung L, Pourzand L, Volkmann ER Abstract Infection with the coronavirus disease 2019 (Covid-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), manifests in a myriad of ways ranging from asymptomatic disease to pneumonia and acute respiratory distress syndrome. Advanced age and underlying cardiovascular/pulmonary conditions appear to increase the risk for Covid-19 complications [1,2]. PMID: 32934125 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
Abstract COVID-19 pandemic is a serious global health issue today due to the rapid human to human transmission of SARS-CoV-2, a new type of coronavirus that causes fatal pneumonia. SARS -CoV-2 has a faster rate of transmission than other coronaviruses such as SARS and MERS and until now there are no approved specific drugs or vaccines for treatment. Thus, early diagnosis is crucial to prevent the extensive spread of the disease. The reverse transcription-polymerase chain reaction (RT-PCR) is the most routinely used method until now to detect SARS-CoV-2 infections. However, several other faster and accurate assays ...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research
Conclusion: This series of autopsies from patients with COVID-19 confirms the observation that the majority of severely affected patients have significant pulmonary pathology. However, many patients also have widespread microscopic thromboses, as well as characteristic findings in the liver and lymph nodes.Pathobiology
Source: Pathobiology - Category: Pathology Source Type: research
Coronavirus disease 2019 (COVID-19), an acute onset pneumonia caused by a novel Betacoronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in the Wuhan City of China in December 2019 and evolved into a global pandemic. To date, there are no proven drugs or vaccines against this virus. Hence, the situation demands an urgent need to explore all potential therapeutic strategies that can be made available to prevent the disease progression and improve patient outcomes. In absence of clinically proven treatment guidelines, several repurposed drugs and investigational agents are currently being evalua...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the causative agent of a clinical syndrome, coronavirus disease 2019 (COVID-19), associated with mild respiratory tract infections and severe pneumonia (Wu and McGoogan, 2020). However, SARS-CoV-2 has been shown to affect other organs both directly, by binding to specific cellular receptors, and indirectly due to the triggered abnormal inflammatory response( Bourgonje et al., 2020; Ye et al., 2020).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Case Report Source Type: research
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
We describe a rare case of post-infective Acute Motor Axonal Neuropathy (AMAN) variant of Guillain-Barr è Syndrome (GBS) associated with myelitis and anti-GD1b positivity after SARS-CoV-2 infection. The patient referred to the hospital reporting a history of ten days lasting moderate fever, myalgia and anosmia, with the onset of progressive quadriparesis and ascending paraesthesias in the four limbs since five days from defervescence. A chest computed tomography demonstrated interstitial pneumonia with “ground glass opacities”, suggesting Coronavirus disease (COVID-19). The patient exhibited three negati...
Source: Journal of Neurology - Category: Neurology Source Type: research
The COVID-19 pandemic has proven to have significant morbidity and mortality in high risk patient populations including those with cancer. Chronic lymphocytic leukemia (CLL) is an indolent disease and the majority of patients with CLL are under monitoring. Here we present a case of a CLL patient with severe COVID-19 presenting with marked lymphocytosis within 2-3 days of diagnosis. An 80-years old man with treatment na ïve CLL was admitted to our hospital for COVID-19 pneumonia. He was intubated due to hypoxic respiratory failure and developed multi-system organ failure requiring hemodialysis and vasopressor therapy.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research
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