Macrophage Lxr α reduces atherosclerosis in Ldlr-/- mice independent of Arl7 transactivation.

CONCLUSION: Lxrα's anti-atherosclerotic effects in Ldlr-/- mice are not primarily attributable to Lxrα's influence on Arl7 expression. This evidence suggests that Lxrα's effects on plaque inflammation may be more critical to in vivo atherogenesis than its effects on macrophage cholesterol efflux and foam cell development.
PMID: 32736671 [PubMed - as supplied by publisher]

Source: Biochemical and Biophysical Research communications - August 3, 2020 Category: Biochemistry Authors: Yin Y, Zeng S, Li Y, Wu Z, Huang D, Gao P Tags: Biochem Biophys Res Commun Source Type: research