Peroxiredoxin I deficiency increases keratinocyte apoptosis in a skin tumor model via the ROS-p38 MAPK pathway.

In conclusion, the deletion of Prx I triggered the DMBA/TPA-induced skin tumor formation in vivo and in vitro by regulating the reactive oxygen species (ROS)-p38 mitogen-activated protein kinase (MAPK) pathway. These findings provide a theoretical basis for treating skin cancer. PMID: 32736685 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32736685?dopt=Abstract

Source: Biochemical and Biophysical Research communications - August 3, 2020 Category: Biochemistry Authors: Han YH, Zhang YQ, Jin MH, Jin YH, Qiu MY, Li WL, He C, Yu LY, Hyun JW, Lee J, Yoon DY, Sun HN, Kwon T Tags: Biochem Biophys Res Commun Source Type: research