A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters.

In conclusion, a novel bile acid analog A17 was identified to ameliorate NASH in HF-fed hamsters. The potential mechanisms could be contributed to reducing FA uptake, stimulating FA oxidation and relieving inflammation.
PMID: 32738331 [PubMed - as supplied by publisher]

Source: Toxicology and Applied Pharmacology - July 28, 2020 Category: Toxicology Authors: Wang Y, Zhu Y, Niu J, Deng Q, Guo S, Jiang H, Peng Z, Xue Y, Peng H, Xuan L, Pan G Tags: Toxicol Appl Pharmacol Source Type: research