Is heart transplantation a real option in patients with Duchenne syndrome? Inferences from a case report

We describe the case of an 18‐year‐old male patient, affected by DMD and in a wheelchair from the age of 11. He progressively developed dilated cardiomyopathy, and in 2016, at the age of 14 years, he underwent HeartWare LVAD implantation, as destination therapy, without post‐operative complications. He has been followed up for 47 consecutive months; and 30 months after LVAD implantation, he developed an infection of the exit site, treated by antibiotics and surgical toilette. Following this event, on the basis of patient's good general conditions and willingness, we started to consider heart transplant as an option. Before the patient was listed, he underwent accu rate workup, and we found higher values of forced vital capacity, forced expiratory volume in 1 s, and peak expiratory flow, compared with the predicted values of same‐age DMD patients. The patient have neither scoliosis nor need for non‐invasive mechanical ventilation, and finally, he was alwa ys treated with steroids with stable thoraco‐abdominal function over the years. According to these considerations, the patient was listed for heart transplant. In 12 February 2020, at the age of 18 years, the patient underwent heart transplant with no post‐operative complications. Cardiac trans plantation is not considered a valid option for DMD patients, because of the shortage of donor availability and the systemic nature of DMD disease. Considering that this patient had already experienced...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Case Report Source Type: research

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Abstract OBJECTIVE: to analyze the transition of blind women to motherhood from the perspective of Transitions Theory. METHOD: a qualitative, descriptive study, which had as participants 11 blind women. An open interview was conducted using the narrative method. Analysis occurred in the light of Transitions Theory, with approval from the Research Ethics Committee with Human Beings. RESULTS: the age group was 32 to 63 years, mostly Catholic, with social security benefits. Transition to motherhood mainly evidenced the experience when becoming a mother and feelings related to this new phase of life. FI...
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
This study aimed to confirm the correlations among hip extension range of motion, hip extension asymmetry, pain intensity, disability index, and compensatory lumbar movement in patients with nonspecific chronic low back pain. MATERIAL AND METHODS Of 66 patients with nonspecific chronic low back pain and limited hip extension, 59 met the inclusion criteria and were enrolled in the study. Pain intensity, Oswestry Disability Index (ODI), hip range of motion, compensatory lumbar extension, and compensatory lumbar rotation of the subjects were assessed. Pain was measured using a numeric pain rating scale (NPRS), and hip extensi...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 24 September 2020Source: International Journal of Surgery Case ReportsAuthor(s): Didik Librianto, Fachrisal, Ifran Saleh
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
No abstract available
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Online Articles: Letters to the Editor Source Type: research
Background: Diagnostic and interventional flexible bronchoscopy (FB) is increasingly utilized in complex and high-risk patients. Patients are often sedated for comfort and procedure facilitation and hypoxia is commonly observed in this setting. We hypothesized that high-flow nasal oxygen (HFNO) would reduce the incidence of patients experiencing oxygen desaturation. Methods: In this randomized controlled trial, postlung transplant patients booked for FB with transbronchial lung biopsy were assigned to either HFNO or low-flow nasal oxygen (LFNO). The patient and bronchoscopist were blinded to group allocation. The prim...
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
Conclusion: Patients with DAS phenotypes that were treated with endobronchial stenting did not require less airway intervention or have greater final airway patency compared with the nonstented airways. Among the stented patients, the need for airway manipulation did not decrease after stent placement.
Source: Journal of Bronchology and Interventional Pulmonology - Category: Respiratory Medicine Tags: Original Investigations Source Type: research
This article reviews the pathophysiology, presentation, diagnosis, and management of cardiac amyloidosis.
Source: Journal of the American Academy of Physician Assistants - Category: Primary Care Tags: CME: Cardiology Source Type: research
Condition:   Fuchs Dystrophy Intervention:   Sponsor:   State University of New York at Buffalo Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   SARS-CoV Infection;   Corona Virus Infection;   Liver Transplant Recipient;   COVID-19 Intervention:   Sponsor:   Assiut University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Covid19;   Intellectual Disability;   Developmental Disability;   Child Development Disorder Interventions:   Behavioral: General Communication Message;   Behavioral: Focused/Targeted Message;   Behavioral: Best Message Alone;   Behavioral: Best Message + Augmented Message or Implementation Strategy Sponsors:   Washington University School of Medicine;   University of Missouri, Kansas City;   Hugo W. Moser Research Institute at Kennedy Krieger, Inc.;  ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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