Analysis of Hb levels and degree of anemia in relation to genotype in 615 patients with hemoglobin H disease.

CONCLUSION: Patients with Hb H disease in Guangxi have particular gene profiles. The clinical manifestations of various types of Hb H disease are heterogeneous; the Hb levels of patients with deletional Hb H are generally higher than those with non-deletional Hb H (P<0.05) . In-depth knowledge of the gene mutation spectrum of thalassemia in Guangxi can provide a basis for genetic counseling of couples and enable prenatal diagnosis. PMID: 32727230 [PubMed - as supplied by publisher]
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research