Modeling drug resistance in a conjoint normal-tumor setting

Conclusion: The results provide us with a deeper understanding of the possible evolution of normal, drug-responsive, and drug-resistant tumor cells during the cancer progression, which may contribute to improving the therapeutic strategies.
Source: Theoretical Biology and Medical Modelling - Category: Biomedical Science Authors: Source Type: research

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CONCLUSIONS In a summary, by inhibiting the STAT3 activation, esculetin shows potential anticancer effects against the laryngeal cancer. PMID: 31630150 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
In conclusion, AFAP1-AS1 promoted chemotherapy resistance by supressing miR-139-5p expression and promoting RRM2/EGFR/AKT signaling pathway in NSCLC cells.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: Davaro F, May A, McFerrin C, Raza SJ, Siddiqui S, Hamilton Z Abstract INTRODUCTION: To evaluate the overall survival and pathologic downstaging effect of neoadjuvant chemotherapy for upper tract urothelial cell carcinoma. MATERIALS AND METHODS: The National Cancer Database (NCDB) was queried for patients with stage II-IV upper tract urothelial cell carcinoma undergoing definitive surgical resection (nephroureterectomy) from 2004-2015. Patients with metastatic disease were excluded. Cohorts were stratified by receipt of neoadjuvant chemotherapy (NAC). Kaplan-Meier analysis and Cox regression were used t...
Source: Canadian Journal of Urology - Category: Urology & Nephrology Tags: Can J Urol Source Type: research
ACS Applied Materials&InterfacesDOI: 10.1021/acsami.9b15751
Source: ACS Applied Materials and Interfaces - Category: Materials Science Authors: Source Type: research
The combination of trilaciclib and chemotherapy was generally well –tolerated with promising activity in a phase II trial of patients with metastatic triple-negative breast cancer.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
Increasing numbers of breast cancer patients receive neoadjuvant chemotherapy (NACT). We seek to investigate whether baseline mammographic and ultrasound features are associated with complete pathological resp...
Source: Cancer Imaging - Category: Radiology Authors: Tags: Research article Source Type: research
ConclusionsBy analyzing cytokines and proportion of immune cells in body fluid, prognosis of patients with mGC can be predicted. Immune monitoring using body fluid may provide more effective treatment for patients with mGC.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
The aim of this study is to develop a prognostic nomogram for early stage extranodal NK/T-cell lymphoma, nasal-type (ENKL) treated with high-dose radiotherapy (RT). A total of 81 patients at two cancer centers with stage I to IIE ENKL who received chemotherapy (CT) and high-dose RT were retrospectively analyzed. The 5-year OS rate and PFS were 64.7% and 57.5% respectively for the entire group. The development of the nomogram was based on the Cox proportional hazards model. We have implemented the concordance index (C-index) and performed a calibration curve to determine its predictive and discriminatory capacity and compar...
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Original Study Source Type: research
Conclusions. In summary, RES529, the first dual TORC1/TORC2 dissociative inhibitor, lacking affinity for ABCB1/ABCG2 and having good brain penetration, was active in GBM preclinical/murine models giving credence to its use in clinical trial for patients with GBM treated in association with anti-angiogenetic compounds.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
In cell transfer therapy (CTT), immune cells such as innate immune ‐derived natural killer cells and dendritic cells as well as acquired immune‐related T lymphocytes such as tumor‐infiltrating lymphocytes and cytokine‐activated or genetically modified peripheral blood T cells are used in the management of cancer. These therapies are increasingly becoming th e most used treatment modality in cancer after tumor resection, chemotherapy, and radiotherapy. In adoptive cell transfer, the lymphocytes isolated from either a donor or the patient are modified ex vivo and reinfused to target malignant cells. Transferring in v...
Source: IUBMB Life - Category: Research Authors: Tags: CRITICAL REVIEW Source Type: research
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