Red light-triggered photoreduction on a nucleic acid template.

Red light-triggered photoreduction on a nucleic acid template.
Chem Commun (Camb). 2020 Jul 30;:
Authors: Dutta S, Rühle J, Schikora M, Deussner-Helfmann N, Heilemann M, Zatsepin T, Duchstein P, Zahn D, Knör G, Mokhir A
Abstract
Conjugate Sn(iv)(pyropheophorbide a)dichloride-(peptide nucleic acid) catalyzes reduction of azobenzene derivatives in the presence of complementary nucleic acid (NA) upon irridiation with red light (660 nm). This is the first red light-induced NA-templated photoreduction. It is highly sensitive to single mismatches in the NA-template and can detect down to 5 nM NAs.
PMID: 32728684 [PubMed - as supplied by publisher]

Source: Chemical Communications - July 29, 2020 Category: Chemistry Authors: Dutta S, Rühle J, Schikora M, Deussner-Helfmann N, Heilemann M, Zatsepin T, Duchstein P, Zahn D, Knör G, Mokhir A Tags: Chem Commun (Camb) Source Type: research