Catalytic and enantioselective oxa-Piancatelli reaction using a chiral vanadium complex.

Catalytic and enantioselective oxa-Piancatelli reaction using a chiral vanadium complex.
Chem Commun (Camb). 2020 Jul 31;:
Authors: Schober L, Sako M, Takizawa S, Gröger H, Sasai H
Abstract
An enantioselective oxa-Piancatelli reaction was established for the first time using a chiral vanadium(v) catalyst. The dual Brønsted and Lewis acid properties of the vanadium catalyst afforded 4-hydroxycyclopent-2-enone derivatives in up to 90% yields and with 93 : 7 enantiomeric ratios, as well as >20 : 1 diastereomeric ratios.
PMID: 32735309 [PubMed - as supplied by publisher]

Source: Chemical Communications - July 30, 2020 Category: Chemistry Authors: Schober L, Sako M, Takizawa S, Gröger H, Sasai H Tags: Chem Commun (Camb) Source Type: research