Unconventional biocatalytic approaches for the synthesis of chiral sulfoxides.

Unconventional biocatalytic approaches for the synthesis of chiral sulfoxides. Chembiochem. 2020 Jul 31;: Authors: Anselmi S, Aggarwal N, Moody TS, Castagnolo D Abstract Sulfoxides are a class of organic compounds that finds wide application in medicinal and organic chemistry. Several biocatalytic approaches have been developed to synthesise enantioenriched sulfoxides, mainly exploiting oxidative enzymes. Recently, the use of reductive enzymes such as Msr and Dms has emerged as new and alternative method to obtain enantiopure sulfoxides from racemic mixtures. In parallel, novel oxidative approaches, employing non-classical solvents such as ionic liquids (ILs) and deep eutectic solvents (DESs), have been developed as greener and more sustainable biocatalytic synthetic pathways. This minireview aims at highlighting the recent advances made in the biocatalytic synthesis of enantioenriched sulfoxides employing unconventional approaches, such as the use of reductive enzymes and IL/DES solvents. PMID: 32735057 [PubMed - as supplied by publisher]
Source: Chembiochem - Category: Biochemistry Authors: Tags: Chembiochem Source Type: research