Concise Total Synthesis of (+)-Atlanticone C
Synlett DOI: 10.1055/s-0040-1707215 The first enantioselective total synthesis of (+)-atlanticone C is described. The complex tricyclic protoilludane core was rapidly assembled by a photochemical reaction cascade starting from an easily accessible indanone precursor (3 steps). Optimization of an enantioselective Corey–Bakshi–Shibata reduction permitted a catalytic chiral resolution of the racemic photoproduct (45% over two steps; up to 98% ee). The enantiomerically enriched photoproduct was efficiently transformed into the (+)-enantiomer of atlanticone C (10 steps; 18% yield), and the absolute configuration of naturally occurring (–)-atlanticone C was thereby determined. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: Synlett - Category: Chemistry Authors: Proessdorf, Johanna Zech, Andreas Jandl, Christian Bach, Thorsten Tags: letter Source Type: research
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