The role of autophagy in the pathogenesis of ischemic stroke.

The role of autophagy in the pathogenesis of ischemic stroke.
Curr Neuropharmacol. 2020 Jul 28;:
Authors: Shi Q, Cheng Q, Chen C
Abstract
Autophagy is a strictly regulated process which degrades and recycles long-lived or misfolded proteins and damaged organelles for the maintenance of energy and function homeostasis of cells. Insufficient oxygen and glucose supply caused by cerebral ischemia leads to higher ratio of AMP/ATP, which will activate AMPK pathway to initiate the process of autophagy. Accumulating evidence shows that autophagy participates in the pathogenesis of ischemic stroke as a doubleedge sword. However, the exact role of autophagy in the pathogenesis of ischemic stroke is controversial and yet to be elucidated. In this review, we expounded the autophagy pathway both in physiological condition and in ischemic stroke. We also focused on discussing the double-edge sword effect of autophagy in brain ischemia and its underlying mechanisms. In addition, we reviewed potential therapeutic strategies for ischemic stroke targeting autophagy pathway.
PMID: 32727333 [PubMed - as supplied by publisher]

Source: Current Neuropharmacology - July 27, 2020 Category: Drugs & Pharmacology Authors: Shi Q, Cheng Q, Chen C Tags: Curr Neuropharmacol Source Type: research