Heparanase level and procoagulant activity are increased in thalassemia and attenuated by JAK-2 inhibition

Patients with thalassemia demonstrate an increased risk of thrombotic events that is augmented following splenectomy. Heparanase protein, aside from enhancing cancer progression, angiogenesis and inflammation, is shown to activate the coagulation system through direct interaction with tissue factor (TF). Additionally, erythropoietin, elevated in anemic patients, is found to upregulate heparanase expression via the JAK-2 pathway. The study aim was to explore the heparanase profile in thalassemia.

Source: American Journal of Pathology - July 30, 2020 Category: Pathology Authors: Hussam Ghoti, Shanny Ackerman, Stefano Rivella, Carla Casu, Yona Nadir Tags: Regular Article Source Type: research