Gabapentinoid Benefit and Risk Stratification: Mechanisms Over Myth

ConclusionsGabapentinoids remain a vital tool in the pain physician ’s multimodal armamentarium, but these drugs may not be effective in every clinical situation. Individuals with central sensitization and pain associated with slow-wave sleep deficits and potentially persons with comorbid addictions may benefit the most. The gabapentinoids appear to possess no add ictive potential on their own, based on laboratory and clinical data, but they may be abused by persons with opioid use disorders; consequently, cautious risk stratification must take place.
Source: Pain and Therapy - Category: Anesthesiology Source Type: research