Total Synthesis of Ascospiroketal B

Synlett DOI: 10.1055/s-0040-1706405 An enantioselective total synthesis of the marine tricyclic polyketide ascospiroketal B, previously isolated from the marine-derived fungus Ascochyta salicorniae, was accomplished in 21 steps by using an improved route. The intriguing 5,5-spiroketal-cis-fused-γ-lactone core was constructed through rearrangement of an epoxide, in conjunction with an acid-mediated spiroketalization. [...] © Georg Thieme Verlag Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text

Source: Synlett - July 29, 2020 Category: Chemistry Authors: Hara, Yoshiyori Kamaike, Kazuo Ota, Koichiro Miyaoka, Hiroaki Tags: letter Source Type: research