The catalytic mechanism of sulfoxide synthases.

The catalytic mechanism of sulfoxide synthases.
Curr Opin Chem Biol. 2020 Jul 26;59:111-118
Authors: Stampfli AR, Seebeck FP
Abstract
Sulfoxide synthases are non-heme iron enzymes that catalyze oxidative carbonsulfur bond formation in the biosynthesis of thiohistidines such as ergothioneine and ovothiol. The catalytic mechanism of these enzymes has been studied by protein crystallography, steady-state kinetics, non-natural amino acid incorporation and computational modeling. This review discusses the current status of this research and also highlights similarities between the CS bond forming activity of sulfoxide synthases with that of synthetic coordination compounds.
PMID: 32726707 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - July 25, 2020 Category: Biochemistry Authors: Stampfli AR, Seebeck FP Tags: Curr Opin Chem Biol Source Type: research