Genome-wide association study identifies a novel maternal gene  × stress interaction associated with spontaneous preterm birth.

CONCLUSION: We demonstrated a significant maternal PTPRD × stress interaction on sPTB risk. This finding, if further confirmed, may provide new insight into individual susceptibility to stress-induced sPTB.
IMPACT: This was the first preterm study to demonstrate a significant genome-wide gene-stress interaction in African Americans, specifically, PTPRD gene variants can interact with maternal perceived stress to affect risk of spontaneous preterm birth.The PTPRD × maternal stress interaction was demonstrated in African Americans and replicated in both African Americans and Caucasians from the GPN study.Our findings highlight the importance of considering genetic susceptibility in assessing the role of maternal stress on spontaneous preterm birth.
PMID: 32726798 [PubMed - as supplied by publisher]

Source: Pediatric Research - July 28, 2020 Category: Pediatrics Authors: Hong X, Surkan P, Zhang B, Keiser A, Ji Y, Ji H, Burd I, Bustamante-Helfrich B, Ogunwole S, Tang WY, Liu L, Pearson C, Cerda S, Zuckerman B, Hao L, Wang X Tags: Pediatr Res Source Type: research