Haematopoietic stem cell transplantation NG164, NICE (updated 29th July 2020)

The purpose of this guideline is to maximise the safety of patients who need haemopoietic stem cell transplantation and make the best use of NHS resources, while protecting staff from infection. On 29 July 2020, we amended recommendations on advice and testing for COVID-19 for patients and donors, and removed recommendations on deferring treatment for some patients to reflect changes in the risk of infection and the capacity in services. See 2 External 0 0 0 update information false https://www.nice.org.uk/guidance/ng164/chapter/Update-information true false%> for details.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news

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Coronavirus disease 2019 (COVID-19) is affecting millions of patients worldwide. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which belongs to the family Coronaviridae, with 80% genomic similarities to SARS-CoV. Lymphopenia was commonly seen in infected patients and has a correlation to disease severity. Thrombocytopenia, coagulation abnormalities, and disseminated intravascular coagulation were observed in COVID-19 patients, especially those with critical illness and non-survivors. This pandemic has caused disruption in communities and hospital services, as well as straining blood prod...
Source: Acta Haematologica - Category: Hematology Source Type: research
Abstract Coronavirus disease 2019 (COVID-19) is affecting millions of patients worldwide. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which belongs to the family Coronaviridae, with 80% genomic similarities to SARS-CoV. Lymphopenia was commonly seen in infected patients and has a correlation to disease severity. Thrombocytopenia, coagulation abnormalities, and disseminated intravascular coagulation were observed in COVID-19 patients, especially those with critical illness and non-survivors. This pandemic has caused disruption in communities and hospital services, as well as st...
Source: Acta Haematologica - Category: Hematology Authors: Tags: Acta Haematol Source Type: research
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons. Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
;o CM Abstract OBJECTIVE: To describe the experience of nursing, in adopting containment measures, in the care of patients undergoing hematopoietic stem cell transplantation to avoid COVID-19. METHODS: Experience report. RESULTS: Containment measures involve those recommended by major health organizations, such as hand hygiene, social isolation, identification and monitoring of suspected or confirmed cases; and also the local measures implemented in the health service, such as the reduction in the number of hospitalizations for transplantation, clinical screening of outpatients entering the service, moni...
Source: Revista Brasileira de Enfermagem - Category: Nursing Authors: Tags: Rev Bras Enferm Source Type: research
Aplastic anaemia is a rare and serious bone marrow failure disorder causing a high risk of life-threatening bleeding and infections, and requiring frequent hospital admissions. Current definitive treatments for aplastic anaemia are stem cell transplant or immunosuppressive therapy with antithymocyte globulin and/or ciclosporin. Stem cell transplant is a procedure in which a patient receives healthy stem cells to replace damaged stem cells. Immunosuppressive treatment is where drugs are given to lower the body's immune response. Stem cell transplant and antithymocyte globulin treatment require hospital admission
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
A Brazilian man infected with the AIDS virus has shown no sign of it for more than a year since he stopped HIV medicines after an intense experimental drug therapy aimed at purging hidden, dormant virus from his body, doctors reported Tuesday. The case needs independent verification and it’s way too soon to speculate about a possible cure, scientists cautioned. “These are exciting findings but they’re very preliminary,” said Dr. Monica Gandhi, an AIDS specialist at the University of California, San Francisco. “This has happened to one person, and one person only,” and it didn’t suc...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized HIV/AIDS News Desk wire Source Type: news
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is an unprecedented challenge [1]. High dose chemotherapy (HDCT) with autologous stem cell transplantation (ASCT) represents a potentially curative option for testicular germ cell tumor (TGCT) [2], however, to our knowledge, to date there have been no reports on these regimens in patients with COVID-19.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Letter to the Editor Source Type: research
There is no situation so terrible that it will not be silently accepted as set in stone, only given that it has lasted for long enough to become routine. So it is with aging, and all of the pain, suffering, and death that accompanies it. The present furor surrounding COVID-19 is unusual for casting at least a little light upon the point that infectious disease largely kills older people, and in very large numbers, year in and year out. In the normal course of affairs, no-one cares until it is their turn to be old, frail, and vulnerable. The immune system decays with age, becoming simultaneously overactive (inflammag...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first identified in Wuhan, China; and spread all over the world. Reverse-transcription polymerase chain reaction (RT-PCR) test for SARS-CoV-2 usually returns to negative in 20 days post-infection, but prolonged positivity has been reported up to 63 days. A case whose viral shedding lasted 60 days is reported from China. Herein we report a patient with a history of autologous stem cell transplantation (ASCT) for lymphoma whose RT-PCR test remained positive for SARS-CoV-2 for 74 days.
Source: Transfusion and Apheresis Science - Category: Hematology Authors: Tags: Case Report Source Type: research
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