Ginsburg Hospitalized for Non-Surgical Procedure

It's been a tough month, health-wise, for Ginsburg. On July 17 she announced that she underwent chemotherapy to help fight a recurrence of pancreatic cancer, CNN reported.
Source: WebMD Health - Category: Consumer Health News Source Type: news

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Abstract Low preoperative physical function in cancer patients is associated with postoperative complications; however, there have been no reports on the benefits of in-hospital preoperative rehabilitation on preoperative physical function in patients with pancreatic cancer. Therefore, the aim of this study was to quantitatively determine the effects of preoperative in-hospital rehabilitation provided under the supervision of a physiotherapist, on preoperative physical function in patients with pancreatic cancer. The study subjects were 26 patients (15 males, 11 females; age 71.2 ± 8.5 years, range: 51-87 y...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
Publication date: Available online 11 August 2020Source: Journal of Geriatric OncologyAuthor(s): Rebekah Rittberg, Hanbo Zhang, Pascal Lambert, Robert Kudlovich, Christina A. Kim, David E. Dawe
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
NF-κB transcription factors, driven by the IRAK/IKK cascade, confer treatment resistance in pancreatic ductal adenocarcinoma (PDAC), a cancer characterized by near-universal KRAS mutation. Through reverse-phase protein array and RNA sequencing we discovered that IRAK4 also contributes substantially to MAPK activation in KRAS-mutant PDAC. IRAK4 ablation completely blocked RAS-induced transformation of human and murine cells. Mechanistically, expression of mutant KRAS stimulated an inflammatory, autocrine IL-1β signaling loop that activated IRAK4 and the MAPK pathway. Downstream of IRAK4, we uncovered TPL2 (also k...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
In this study, ICD was found to synergistically inhibit cell viability with gemcitabine in pancreatic cancer cells. A microarray analysis showed that ICD can inhibit the upregulation of STAT3 and EMT in pancreatic cancer cells induced by gemcitabine. STAT3 is closely related to tumor EMT, migration and invasion. After knocking down the expression of STAT3 in pancreatic cancer cells, the combination index (CI) of ICD and gemcitabine decreased. ICD can reverse the increase in the expression of EMT-related transcription factors and proteins caused by gemcitabine, thereby inhibiting the enhanced cell migration and invasion abi...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
AbstractObjectivesTo assess the proportion of missed/misinterpreted imaging examinations of pancreatic ductal adenocarcinoma (PDAC), and their association with the diagnostic interval and survival.MethodsTwo hundred fifty-seven patients (mean age, 71.8  years) diagnosed with PDAC in 2014–2015 were identified from the Nova Scotia Cancer Registry. Demographics, stage, tumor location, and dates of initial presentation, diagnosis, and, if applicable, surgery and death were recorded. US, CT, and MRI examinations during the diagnostic interval were i ndependently graded by two radiologists using the RADPEER system; di...
Source: European Radiology - Category: Radiology Source Type: research
Preoperative biliary stenting is required for patients with obstructive jaundice from pancreatic adenocarcinoma who are receiving neoadjuvant chemotherapy. While in most patients this approach results in durable biliary drainage, some patients develop cholangitis during neoadjuvant treatment. Further, several studies have shown that preoperative cholangitis in patients with hepatobiliary malignancies can result in substantially unfavorable outcomes. The aim of this study was to evaluate the impact of preoperative cholangitis in patients who underwent pancreaticoduodenectomy after completing neoadjuvant chemotherapy.
Source: American Journal of Surgery - Category: Surgery Authors: Source Type: research
ConclusionsHistorical survival in patients with advanced and metastatic pancreas cancer is poor. Results of this DDR-subset of patients do show significantly superior outcomes, likely secondary to exposure to platinum drugs. This data, alongside other similar cohorts, would favor the DDR-genes being a predictive marker with improved survival if exposed to these drugs and the new class of drugs, PARP-inhibitors.
Source: Hereditary Cancer in Clinical Practice - Category: Cancer & Oncology Source Type: research
AbstractIrreversible electroporation (IRE) is a non-thermic ablation therapy which has been proposed for locally advanced pancreatic adenocarcinoma (LAPC) as well as for the local control of other types of tumors (kidney or liver). Its use has been extended in the last few years worldwide. Its advantage over other ablation techniques is that it only affects the lipids bilayer of the cell membrane avoiding vascular damage. Safety and viability have been demonstrated in recent studies. Overall survival seems (OS) to improve when it is combined with chemotherapy compared to chemotherapy with or without radiotherapy. Clinical ...
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
One-third of patients with pancreatic cancer has unresectable locally advanced disease at the time of diagnosis, and current treatment for these patients consists of a combination of chemotherapy and radiation therapy [1,2]. Historically, gemcitabine has been used as first-line chemotherapy after a pivotal multi-institutional trial showed both substantial clinical benefit and modestly improved survival with gemcitabine compared to 5-fluorouracil [3]. Recently, multiagent chemotherapy regimens have shown significant promise [4-7].
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
ConclusionsIn patients with resected invasive IPMNs, adjuvant chemo(radiation) was associated with significantly improved overall survival only in presence of nodal metastases. This finding can help clinicians to select adjuvant treatment in a patient-tailored fashion.
Source: Annals of Surgical Oncology - Category: Cancer & Oncology Source Type: research
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