Long-term use of proton pump inhibitors as a risk factor for various adverse manifestations.
Long-term use of proton pump inhibitors as a risk factor for various adverse manifestations. Therapie. 2020 Jul 09;: Authors: Koyyada A Abstract The long-term use of proton pump inhibitors (PPIs) can lead to increased gastric pH, hypochlorhydria and in some cases to achlorhydria when compared to other acid-suppressing agents like histamine-2 (H2) receptor blockers and antacids. These consequences by the use of long-term PPIs may lead to significant vitamin (B12 and C) and mineral (iron, calcium and magnesium) deficiencies which needs gastric acid for their absorption and bioavailability. Long-term use of PPIs by the pregnant patients may impose a potential risk of congenital malformations. Various studies have recommended the life style modifications and antacid use as first choice among pregnant womens by preserving PPIs (omeprazole as a safe choice of PPI) for severe conditions of gastroesophageal reflux disease. The long-term acid suppression by PPIs can also lead to enteric, respiratory and urinary tract infections. The hypochlorhydria by chronic PPIs use may induce hypergastrinemia, which ultimately mediates the gastric polyps, gastric carcinoids and gastric cancer. The concomitant use of PPIs with antiplatelet drugs like clopidogrel can impose the patients to major adverse cardiac events. This review has enlisted the comprehensive information regarding the adverse effects induced by long-term use of PPIs and their possible relations. Considerable s...
Deaths among people who have been fully vaccinated remain rare, but older adults and those with compromised immune systems are at much higher risk.
AbstractSecond-line treatment options for patients with relapsed, extensive-stage small cell lung cancer (ES-SCLC) are limited, and even with currently available treatments, prognosis remains poor. Until recently, topotecan (a topoisomerase I inhibitor) was the only drug approved by the United States (US) Food and Drug Administration (FDA) for the management of ES-SCLC following progression after first-line treatment with etoposide plus a platinum derivative (EP; carboplatin preferred). With the most recent approval of EP plus a prog rammed death ligand 1 (PD-L1) inhibitor, there are now more therapeutic options...
ConclusionThe dermatologist density in Bavaria correlates positively with the incidence of malignant melanoma. Despite an increased incidence, mortality was not elevated in the respective administrative regions.
Colin Powell, the first Black secretary of State and chairman of the Joint Chiefs of Staff, dies of COVID-19 complications after bout with blood cancer.
The WHO lists antimicrobial resistance as a top ten global health threat, saying that by 2050 it will kill more people than cancer. Could novel vaccines provide new ways to defeat superbugs?
Doctors say Colin Powell's age, his battle with multiple myeloma - a type of blood cancer - and Parkinson's contributed to his heightened risk of death from Covid despite being fully vaccinated.
Seattle-based Umoja Biopharma on Monday named Clay Siegall as chairman of its board of directors. Siegall is the CEO and co-founder of Bothell-based Seagen, a biotech company that went public on the Nasdaq in 2001. Siegall co-founded the company in 1998. "Clay's vast scientific training and wealth of experience, particularly his emphasis on targeted cancer therapies and ability to build a com pany from drug discovery to commercial-stage, will be a crucial part of Umoja's continued growth," Andy…
Medicare spent nearly $600 million over a three-year period for cancer care involving four Food and Drug Administration-approved drugs later found to provide no clinical benefit for certain forms of the disease.
Colin Powell had a form of blood cancer that saps natural immunity and also undermines the effects of vaccines like the ones used against Covid-19.
The death of Colin Powell, an 84-year-old former four-star general who served as Chairman of the Joint Chiefs of Staff under U.S. President George H.W. Bush and Secretary of State under President George W. Bush and is perhaps best known for his role in bringing the U.S. into its second war in Iraq, is a high-profile reminder of a grim reality: COVID-19 is not just a pandemic of the unvaccinated, as current president Joe Biden likes to say, but a pandemic of the elderly, too. From early on in the pandemic, we’ve known the virus disproportionately kills older people, and the overall data make that pretty clear: About 5...
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