LncRNA SNHG12 improves cerebral ischemic-reperfusion injury by activating SIRT1/FOXO3a pathway through inhibition of autophagy and oxidative stress.

CONCLUSION: In conclusion, lncRNA SNHG12 increased cell activity and inhibited oxidative stress through inhibition of SIRT1/FOXO3a signaling-mediated autophagy in HT22 cells of I/R model. This study might provide new potential therapeutic targets for further investigating the mechanisms in cerebral I/R injury and provide. PMID: 32718291 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32718291?dopt=Abstract

Source: Current Neurovascular Research - July 26, 2020 Category: Neurology Authors: Wu Y, Huang Y, Cai J, Zhang D, Liu S, Pang B Tags: Curr Neurovasc Res Source Type: research

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